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Membrane-type 1 metalloproteinase is upregulated in microglia/brain macrophages in neurodegenerative and neuroinflammatory diseases

Item Type:Article
Title:Membrane-type 1 metalloproteinase is upregulated in microglia/brain macrophages in neurodegenerative and neuroinflammatory diseases
Creators Name:Langenfurth, A. and Rinnenthal, J.L. and Vinnakota, K. and Prinz, V. and Carlo, A.S. and Stadelmann, C. and Siffrin, V. and Peaschke, S. and Endres, M. and Heppner, F. and Glass, R. and Wolf, S.A. and Kettenmann, H.
Abstract:We previously reported that glioma cells induce the expression of membrane-type 1 metalloproteinase (MT1-MMP or MMP-14) in tumor-associated microglia/macrophages and promote tumor growth, whereas MMP-14 expression in microglia under physiological conditions is very low. Here, we show that the increase in MMP-14 expression is also found in microglia/macrophages associated with neurodegenerative and neuroinflammatory pathologies in mouse models as well as in human biopsies or post-mortem tissue. We found that microglial/macrophage MMP-14 expression was upregulated in Alzheimer's disease tissue, in active lesions of multiple sclerosis, and in tissue from stage II stroke as well as in the corresponding mouse models for the human diseases. In contrast, we observed no upregulation for MMP-14 in microglia/macrophages in the early phase of stroke or in the corresponding mouse model, in human amyotrophic lateral sclerosis (ALS) tissue or in a mouse model of ALS as well as in human cases of acute brain trauma. These data indicate that MMP-14 expression is not a general marker for activated microglia/macrophages but is upregulated in defined stages of neuroinflammatory and neurodegenerative diseases and that there is generally a good match between mouse models and human brain pathologies.
Keywords:Microglia, Macrophages, Metalloproteinase, MT1-MMP, MMP-14, Neurodegeneration, Neuroinflammation, Trauma, Alzheimer's Disease, Multiple Sclerosis, Stroke, Amyotrophic Lateral Sclerosis, Animals, Mice
Source:Journal of Neuroscience Research
ISSN:0360-4012
Publisher:Wiley (U.S.A.)
Volume:92
Number:3
Page Range:275-286
Date:March 2014
Official Publication:https://doi.org/10.1002/jnr.23288
PubMed:View item in PubMed

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