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Studying Epstein-Barr virus pathologies and immune surveillance by reconstructing EBV infection in mice

Item Type:Article
Title:Studying Epstein-Barr virus pathologies and immune surveillance by reconstructing EBV infection in mice
Creators Name:Yasuda, T. and Wirtz, T. and Zhang, B. and Wunderlich, T. and Schmidt-Supprian, M. and Sommermann, T. and Rajewsky, K.
Abstract:Epstein-Barr virus (EBV) is a γ herpes virus endemic in humans and transforming human B lymphocytes. It causes a variety of human pathologies ranging from infectious mononucleosis upon acute infection to EBV-driven B-cell lymphomas. In humans, EBV-infected cells are under powerful immune surveillance by T and NK cells. If this immune surveillance is compromised as in immunosuppressed (AIDS- or posttransplantation) patients, the virus can spread from rare, EBV-containing cells and cause life-threatening pathologies. We have found that EBV immune surveillance and lymphomagenesis can be modeled in mice by targeted expression of key EBV proteins in the B-cell lineage. As EBV does not infect mouse B cells and mice have thus not coevolved with the virus, EBV exploits basic modes of the host immune response to optimize its coexistence with the host.
Keywords:Acute Disease, Animal Disease Models, B-Cell Lymphoma, B-Lymphocytes, Epstein-Barr Virus Infections, Immunologic Surveillance, Immunosuppression, Signal Transduction, T-Lymphocytes, Viral Matrix Proteins, Animals, Mice
Source:Cold Spring Harbor Symposia on Quantitative Biology
ISSN:0091-7451
Publisher:Cold Spring Harbor Laboratory Press (U.S.A.)
Volume:78
Page Range:259-263
Date:15 November 2013
Official Publication:https://doi.org/10.1101/sqb.2013.78.020222
PubMed:View item in PubMed

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