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Effects of tamoxifen, droloxifene and 17beta-estradiol on Rauscher mouse leukemogenesis

Item Type:Article
Title:Effects of tamoxifen, droloxifene and 17beta-estradiol on Rauscher mouse leukemogenesis
Creators Name:Sydow, G. and Wunderlich, V.
Abstract:The effects of tamoxifen (TAM), its 3-hydroxy congener droloxifene (DROL) and 17 beta-estradiol were investigated on leukemogenesis induced in BALB/c mice by Rauscher murine leukemia virus (RLV). Multiple applications of each compound, in a dose-dependent manner, resulted in reduced virus titer in the serum, delayed onset of splenomegaly and significant prolongation of survival. Although 17 beta-estradiol proved most effective, prevention of disease was not achieved either by short- or long-term treatment with any of the drugs tested.
Keywords:Tamoxifen, Droloxifene, 17{beta}-Estradiol, Leukemogenesis, Retroviruses, Rauscher Murine Leukemia, Animals, Mice
Source:Cancer Letters
ISSN:0304-3835
Publisher:Elsevier (The Netherlands)
Volume:82
Number:1
Page Range:89-94
Date:15 July 1994
Official Publication:https://doi.org/10.1016/0304-3835(94)90150-3
PubMed:View item in PubMed

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