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Complement activation in vascular remodeling and organ damage

Item Type:Review
Title:Complement activation in vascular remodeling and organ damage
Creators Name:Shagdarsuren, E. and Mueller, D.N. and Weber, C. and Zernecke, A.
Abstract:Vascular remodeling is an active process of alterations as part of structural adaptations in response to injuries. In the process of remodeling, vessel wall cells can not only secrete complement components, but also represent potential targets of active products of the activated complement cascade, thus altering the important interplay of vessel wall cells contributing to vascular remodeling. The complement system may thus constitute a potential target in the prevention of vascular remodeling.
Keywords:Angiogenesis, Atherosclerosis, Blood Vessel Wall, Complement Activation, Complement Blood Level, Complement Deficiency, Complement System, Endothelium Cell, Lipid Storage, Macrophage Activation, Organ Injury, Protein Function, Risk Factor, Smooth Muscle Fiber, Thrombocyte Activation, Vascular Smooth Muscle
Source:Drug Discovery Today: Disease Mechanisms
Page Range:e299-e306
Date:December 2008
Official Publication:https://doi.org/10.1016/j.ddmec.2008.09.006

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