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The role of IP(3)R clustering in Ca(2+) signalinG

Item Type:Article
Title:The role of IP(3)R clustering in Ca(2+) signalinG
Creators Name:Skupin, A. and Falcke, M.
Abstract:Ca(2+) is the most important second messenger controlling a variety of intracellular processes by oscillations of the cytosolic Ca(2+) concentration. These oscillations occur by Ca(2+) release from the endoplasmic reticulum (ER) into the cytosol through channels and the re-uptake of Ca(2+) into the ER by pumps. A common channel type present in many cell types is the inositol trisphosphate receptor (IP(3)R), which is activated by IP(3) and Ca(2+) itself leading to Ca(2+) induced Ca(2+) release (CICR). We have shown in an experimental study, that Ca(2+) oscillations are sequences of random spikes that occur by wave nucleation. We use here our recently developed model for Ca(2+) dynamics in 3 dimension to illuminate the role of IP(3)R clustering within spatial extended systems.
Keywords:Cell Signaling, Calcium Oscillations, Modeling, Clustering, Animals
Source:Genome Informatics
Series Name:Genome Informatics
Title of Book:Genome Informatics 2008
Page Range:15-24
Date:June 2008
Official Publication:https://doi.org/10.1142/9781848163003_0002
PubMed:View item in PubMed

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