Neuronale Korrelate lexikalischen Suchverhaltens in der aphasischen Spontansprache: Ein Einzelfall [Neural correlates of lexical retrieval in aphasic spontaneous language: a single-case study]

Item Type:	Article
Title:	Neuronale Korrelate lexikalischen Suchverhaltens in der aphasischen Spontansprache: Ein Einzelfall [Neural correlates of lexical retrieval in aphasic spontaneous language: a single-case study]
Creators Name:	Tillmanns, E. and Meffert, E. and Heim, S. and Frauenrath, T. and Huber, W. and Amunts, K. and Grande, M.
Abstract:	Brain imaging studies localising language functions in the brain mainly target different aspects of unimpaired language at the word and sentence level. Very few studies explore continuous language production. Most studies investigating the functional recovery in aphasia concentrate on preserved language functions and ignore aphasic symptoms. The neural correlates of aphasic symptoms in spontaneous language remain largely unknown. In this single-case study aphasic symptoms in continuous speech were studied with functional magnetic resonance imaging (fMRI). During fMRI, spontaneous language was elicited by means of pictures showing complex situations that had to be described. The implicit baseline condition was represented by episodes of rest between the pictures. Spontaneous language was transcribed and analyzed by means of a newly developed scheme which considered different aspects of unimpaired and impaired spontaneous language and allowed for a comparison of the different conditions. Event-related analysis was conducted by defining events of one second and assigning them to conditions according to the scheme. The results of this single case with moderate amnesic aphasia showed that it is possible to assess the neural correlates of spontaneous language and lexical retrieval. During unimpaired language production and anomia, speech and language relevant brain areas and areas supporting monitoring, attentional and visual processes were activated. When a word could not be retrieved successfully, bilateral inferior frontal and temporo-parietal activations were found, supporting phonological and semantic processes in retrieving the word form. Once the latter was accessed successfully, no significant difference to the activations of unimpaired speech could be detected. The results of other aphasic patients with anomia and other symptoms will show whether aphasic symptoms are related to typical activation patterns.
Keywords:	Spontaneous Language, Aphasia, fMRI, Anomia
Source:	Sprache - Stimme - Gehoer
ISSN:	0342-0477
Publisher:	Thieme
Volume:	35
Number:	2
Page Range:	e60-e67
Date:	June 2011
Official Publication:	https://doi.org/10.1055/s-0031-1271760

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