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Accurate and universal delineation of prokaryotic species

Item Type:Article
Title:Accurate and universal delineation of prokaryotic species
Creators Name:Mende, D.R. and Sunagawa, S. and Zeller, G. and Bork, P.
Abstract:The exponentially increasing number of sequenced genomes necessitates fast, accurate, universally applicable and automated approaches for the delineation of prokaryotic species. We developed specI (species identification tool; http://www.bork.embl.de/software/specI/), a method to group organisms into species clusters based on 40 universal, single-copy phylogenetic marker genes. Applied to 3,496 prokaryotic genomes, specI identified 1,753 species clusters. Of 314 discrepancies with a widely used taxonomic classification, >62% were resolved by literature support.
Keywords:16S Ribosomal RNA, Factual Databases, Genetic Markers, Genome, Phylogeny, Prochlorococcus, Prokaryotic Cells, Proteins, Sequence Alignment, Taxonomic DNA Barcoding
Source:Nature Methods
ISSN:1548-7091
Publisher:Nature Publishing Group (U.S.A.)
Volume:10
Number:9
Page Range:881-884
Date:September 2013
Official Publication:https://doi.org/10.1038/nmeth.2575
PubMed:View item in PubMed

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