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Systemic administration of the phencyclidine compound MK-801 affects stimulus-induced field potentials selectively in layer III of rat medial entorhinal cortex

Item Type:Article
Title:Systemic administration of the phencyclidine compound MK-801 affects stimulus-induced field potentials selectively in layer III of rat medial entorhinal cortex
Creators Name:Gloveli, T. and Iserhot, C. and Schmitz, D. and Castren, E. and Behr, J. and Heinemann, U.
Abstract:Phencyclidine and related compounds such as MK-801 produce psychotic symptoms, which closely resemble schizophrenia. MK-801 causes lesions in different corticolimbic regions including the medial entorhinal cortex (mEC). Using electrophysiological recordings in brain slices we tested whether several hours of systemic administration of MK-801 affect stimulus-induced field potentials (FPs) in the mEC. Stimulus-induced FPs were selectively reduced in layer III, but not in layers II and V of the mEC. In contrast, MK-801 applied acutely over the bath in low concentration had no significant effect on evoked FPs. Since the principal cells of layer III project directly to area CA1 and the subiculum, the selective effects of MK-801 may have implications for the transfer of information to the hippocampus.
Keywords:MK-801, Systemic Administration, Entorhinal Cortex, Field Potentials, In Vitro, Animals, Rats
Source:Neuroscience Letters
ISSN:0304-3940
Publisher:Elsevier (The Netherlands)
Volume:221
Number:2-3
Page Range:93-96
Date:17 January 1997
Official Publication:https://doi.org/10.1016/S0304-3940(96)13307-3
PubMed:View item in PubMed

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