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Effects of serotonin on synaptic and intrinsic properties of rat subicular neurons in vitro

Item Type:Article
Title:Effects of serotonin on synaptic and intrinsic properties of rat subicular neurons in vitro
Creators Name:Behr, J. and Empson, R.M. and Schmitz, D. and Gloveli, T. and Heinemann, U.
Abstract:Intracellular recordings were performed to study the effects of 5-HT on membrane properties and EPSP/IPSP responses of subicular neurons in rat combined hippocampal-entorhinal cortex slices. Application of 5-HT induced in 76% of the investigated subicular cells a hyperpolarization and a reduction of membrane resistance. In bursting neurons, 5-HT caused a reduction of the depolarizing envelope underlying burst discharges and attenuated the subsequent afterhyperpolarization. While 5-HT decreased isolated AMPA/kainate and NMDA receptor-mediated responses as well as slow IPSPs, we could not find a consistent effect on isolated fast IPSPs. Since in approximately 25% of subicular neurons EPSPs and slow IPSPs were reduced without any increase of membrane conductance, we conclude that 5-HT has in addition to membrane effects also effects on synaptic currents.
Keywords:Subiculum, Intracellular Recording, Bursting Cell, Regular Firing Cell, GABAA, GABAB, NMDA, AMPA, 5-HT, Animals, Rats
Source:Brain Research
ISSN:0006-8993
Publisher:Elsevier (The Netherlands)
Volume:773
Number:1-2
Page Range:217-222
Date:31 October 1997
Official Publication:https://doi.org/10.1016/S0006-8993(97)00939-6
PubMed:View item in PubMed

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