Effects of serotonin on synaptic and intrinsic properties of rat subicular neurons in vitro

Item Type:	Article
Title:	Effects of serotonin on synaptic and intrinsic properties of rat subicular neurons in vitro
Creators Name:	Behr, J. and Empson, R.M. and Schmitz, D. and Gloveli, T. and Heinemann, U.
Abstract:	Intracellular recordings were performed to study the effects of 5-HT on membrane properties and EPSP/IPSP responses of subicular neurons in rat combined hippocampal-entorhinal cortex slices. Application of 5-HT induced in 76% of the investigated subicular cells a hyperpolarization and a reduction of membrane resistance. In bursting neurons, 5-HT caused a reduction of the depolarizing envelope underlying burst discharges and attenuated the subsequent afterhyperpolarization. While 5-HT decreased isolated AMPA/kainate and NMDA receptor-mediated responses as well as slow IPSPs, we could not find a consistent effect on isolated fast IPSPs. Since in approximately 25% of subicular neurons EPSPs and slow IPSPs were reduced without any increase of membrane conductance, we conclude that 5-HT has in addition to membrane effects also effects on synaptic currents.
Keywords:	Subiculum, Intracellular Recording, Bursting Cell, Regular Firing Cell, GABAA, GABAB, NMDA, AMPA, 5-HT, Animals, Rats
Source:	Brain Research
ISSN:	0006-8993
Publisher:	Elsevier
Volume:	773
Number:	1-2
Page Range:	217-222
Date:	31 October 1997
Official Publication:	https://doi.org/10.1016/S0006-8993(97)00939-6
PubMed:	View item in PubMed

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