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| Item Type: | Article |
|---|---|
| Title: | Electrical coupling underlies high-frequency oscillations in the hippocampus in vitro |
| Creators Name: | Draguhn, A., Traub, R.D., Schmitz, D. and Jefferys, J.G.R. |
| Abstract: | Coherent oscillations, in which ensembles of neurons fire in a repeated and synchronous manner, are thought to be important in higher brain functions. In the hippocampus, these discharges are categorized according to their frequency as theta (4-10Hz), {gamma} (20-80 Hz) and high-frequency (approximately 200 Hz) discharges, and they occur in relation to different behavioural states. The synaptic bases of theta and {gamma} rhythms have been extensively studied but the cellular bases for high-frequency oscillations are not understood. Here we report that high-frequency network oscillations are present in rat brain slices in vitro, occurring as a brief series of repetitive population spikes at 150-200 Hz in all hippocampal principal cell layers. Moreover, this synchronous activity is not mediated through the more commonly studied modes of chemical synaptic transmission, but is in fact a result of direct electrotonic coupling of neurons, most likely through gap-junctional connections. Thus high-frequency oscillations synchronize the activity of electrically coupled subsets of principal neurons within the well-documented synaptic network of the hippocampus. |
| Keywords: | Action Potentials, Bicuculline, Calcium, Excitatory Amino Acid Antagonists, GABA Antagonists, Gap Junctions, Hippocampus, Neurons, Oscillometry, Animals, Rats |
| Source: | Nature |
| ISSN: | 0028-0836 |
| Publisher: | Nature Publishing Group |
| Volume: | 394 |
| Number: | 6689 |
| Page Range: | 189-192 |
| Date: | 9 July 1998 |
| Official Publication: | https://doi.org/10.1038/28184 |
| PubMed: | View item in PubMed |
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