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Presynaptic kainate receptor mediation of frequency facilitation at hippocampal mossy fiber synapses

Item Type:Article
Title:Presynaptic kainate receptor mediation of frequency facilitation at hippocampal mossy fiber synapses
Creators Name:Schmitz, D. and Mellor, J. and Nicoll, R.A.
Abstract:Inhibition of transmitter release by presynaptic receptors is widespread in the central nervous system and is typically mediated via metabotropic receptors. In contrast, very little is known about facilitatory receptors, and synaptic activation of a facilitatory autoreceptor has not been established. Here we show that activation of presynaptic kainate receptors can facilitate transmitter release from hippocampal mossy fiber synapses. Synaptic activation of these presumed ionotropic kainate receptors is very fast (<10 ms) and lasts for seconds. Thus, these presynaptic kainate receptors contribute to the short-term plasticity characteristics of mossy fiber synapses, which were previously thought to be an intrinsic property of the synapse.
Keywords:6-Cyano-7-nitroquinoxaline-2,3-dione, AMPA Receptors, Excitatory Amino Acid Antagonists, Excitatory Postsynaptic Potentials, Glutamic Acid, Hippocampal Mossy Fibers, Kainic Acid, Kainic Acid Receptors, Neuronal Plasticity, N-Methyl-D-Aspartate Receptors, Synapses, Synaptic Transmission, Animals, Rats
Source:Science
ISSN:0036-8075
Publisher:American Association for the Advancement of Science (U.S.A.)
Volume:291
Number:5510
Page Range:1972-1976
Date:9 March 2001
Additional Information:Erratum in: Science 292(5522):1656.
Official Publication:https://doi.org/10.1126/science.1057105
PubMed:View item in PubMed

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