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The antioxidant idebenone fails to prevent or attenuate chronic experimental autoimmune encephalomyelitis in the mouse

Item Type:Article
Title:The antioxidant idebenone fails to prevent or attenuate chronic experimental autoimmune encephalomyelitis in the mouse
Creators Name:Fiebiger, S.M. and Bros, H. and Grobosch, T. and Janssen, A. and Chanvillard, C. and Paul, F. and Dörr, J. and Millward, J.M. and Infante-Duarte, C.
Abstract:Oxidative stress and mitochondrial dysfunction appear to contribute to neurodegenerative processes during multiple sclerosis (MS). Thus, antioxidants may represent a therapeutic option for MS. The antioxidant idebenone was proven to be beneficial in Friedreich's ataxia and Leber's hereditary optic neuropathy, two disorders caused by mitochondrial alterations. Here we showed that idebenone protected neuronal HT22 cells from glutamate-induced death in vitro. However, in experimental autoimmune encephalomyelitis, idebenone failed to affect disease incidence or onset when applied preventively, or to reduce disease severity when applied therapeutically. Histopathological examination of CNS from idebenone treated mice showed no improvement in inflammation, demyelination, or axonal damage. Thus, we hypothesize that idebenone treatment will likely not benefit patients with MS.
Keywords:Idebenone, Multiple Sclerosis, Oxidative Stress, EAE, Inflammation, Animals, Mice
Source:Journal of Neuroimmunology
ISSN:0165-5728
Publisher:Elsevier (The Netherlands)
Volume:262
Number:1-2
Page Range:66-71
Date:15 September 2013
Official Publication:https://doi.org/10.1016/j.jneuroim.2013.07.002
PubMed:View item in PubMed

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