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Presynaptic kainate receptors impart an associative property to hippocampal mossy fiber long-term potentiation

Item Type:Article
Title:Presynaptic kainate receptors impart an associative property to hippocampal mossy fiber long-term potentiation
Creators Name:Schmitz, D. and Mellor, J. and Breustedt, J. and Nicoll, R.A.
Abstract:Hippocampal mossy fiber synapses show an unusual form of long-term potentiation (LTP) that is independent of NMDA receptor activation and is expressed presynaptically. Using receptor antagonists, as well as receptor knockout mice, we found that presynaptic kainate receptors facilitate the induction of mossy fiber long-term potentiation (LTP), although they are not required for this form of LTP. Most importantly, these receptors impart an associativity to mossy fiber LTP such that activity in neighboring mossy fiber synapses, or even associational/commissural synapses, influences the threshold for inducing mossy fiber LTP. Such a mechanism greatly increases the computational power of this form of plasticity.
Keywords:Electric Stimulation, Excitatory Amino Acid Antagonists, Excitatory Postsynaptic Potentials, Hippocampal Mossy Fibers, Kainic Acid Receptors, Long-Term Potentiation, Neural Pathways, Organ Culture Techniques, Potassium, Presynaptic Terminals, Synaptic Transmission, Animals, Mice, Rats
Source:Nature Neuroscience
ISSN:1097-6256
Publisher:Nature Publishing Group (U.S.A.)
Volume:6
Number:10
Page Range:1058-1063
Date:October 2003
Official Publication:https://doi.org/10.1038/nn1116
PubMed:View item in PubMed

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