Adenosine gates synaptic plasticity at hippocampal mossy fiber synapses

Item Type:	Article
Title:	Adenosine gates synaptic plasticity at hippocampal mossy fiber synapses
Creators Name:	Moore, K.A. and Nicoll, R.A. and Schmitz, D.
Abstract:	The release properties of synapses in the central nervous system vary greatly, not only across anatomically distinct types of synapses but also among the same class of synapse. This variation manifests itself in large part by differences in the probability of transmitter release, which affects such activity-dependent presynaptic forms of plasticity as paired-pulse facilitation and frequency facilitation. This heterogeneity in presynaptic function reflects differences in the intrinsic properties of the synaptic terminal and the activation of presynaptic neurotransmitter receptors. Here we show that the unique presynaptic properties of the hippocampal mossy fiber synapse are largely imparted onto the synapse by the continuous local action of extracellular adenosine at presynaptic A1 adenosine receptors, which maintains a low basal probability of transmitter release.
Keywords:	Adenosine, Adenosine A1Receptor, Ethylmaleimide, GABA-B Receptors, Hippocampal Mossy Fibers, Neuronal Plasticity, Neurotransmitter Agents, Presynaptic Receptors, Sulfhydryl Reagents, Synapses, Synaptic Transmission, Xanthines, Animals, Mice, Rats
Source:	Proceedings of the National Academy of Sciences of the United States of America
ISSN:	0027-8424
Publisher:	National Academy of Sciences
Volume:	100
Number:	24
Page Range:	14397-14402
Date:	25 November 2003
Official Publication:	https://doi.org/10.1073/pnas.1835831100
PubMed:	View item in PubMed

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