Functional GABA uptake at inhibitory synapses in CA1 of chronically epileptic rats

Item Type:	Article
Title:	Functional GABA uptake at inhibitory synapses in CA1 of chronically epileptic rats
Creators Name:	Stief, F. and Piechotta, A. and Gabriel, S. and Schmitz, D. and Draguhn, A.
Abstract:	Inhibitory postsynaptic currents were measured in CA1 pyramidal cells from chronically epileptic rats (pilocarpine model). Tiagabine, a selective inhibitor of the GABA-uptake transporter 1 prolonged currents equally to cells from control animals. Thus, GABA-uptake has an unaltered impact on inhibitory synaptic efficacy in rats with chronic temporal lobe epilepsy, underlining the rational for the use of GABA-uptake blockers in this condition.
Keywords:	Inhibitory Postsynaptic Currents, GABA Uptake, Pilocarpine, Epilepsy, Tiagabine, Animals, Rats
Source:	Epilepsy Research
ISSN:	0920-1211
Publisher:	Elsevier
Volume:	66
Number:	1-3
Page Range:	199-202
Date:	August 2005
Official Publication:	https://doi.org/10.1016/j.eplepsyres.2005.07.006
PubMed:	View item in PubMed

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