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Arc/Arg3.1 is essential for the consolidation of synaptic plasticity and memories

Item Type:Article
Title:Arc/Arg3.1 is essential for the consolidation of synaptic plasticity and memories
Creators Name:Plath, N. and Ohana, O. and Dammermann, B. and Errington, M.L. and Schmitz, D. and Gross, C. and Mao, X. and Engelsberg, A. and Mahlke, C. and Welzl, H. and Kobalz, U. and Stawrakakis, A. and Fernandez, E. and Waltereit, R. and Bick-Sander, A. and Therstappen, E. and Cooke, S.F. and Blanquet, V. and Wurst, W. and Salmen, B. and Boesl, M.R. and Lipp, H.P. and Grant, S.G.N. and Bliss, T.V.P. and Wolfer, D.P. and Kuhl, D.
Abstract:Arc/Arg3.1 is robustly induced by plasticity-producing stimulation and specifically targeted to stimulated synaptic areas. To investigate the role of Arc/Arg3.1 in synaptic plasticity and learning and memory, we generated Arc/Arg3.1 knockout mice. These animals fail to form long-lasting memories for implicit and explicit learning tasks, despite intact short-term memory. Moreover, they exhibit a biphasic alteration of hippocampal long-term potentiation in the dentate gyrus and area CA1 with an enhanced early and absent late phase. In addition, long-term depression is significantly impaired. Together, these results demonstrate a critical role for Arc/Arg3.1 in the consolidation of enduring synaptic plasticity and memory storage.
Keywords:Sysneuro, Signaling, Proteins, Animals, Mice
Publisher:Cell Press
Page Range:437-444
Date:9 November 2006
Official Publication:https://doi.org/10.1016/j.neuron.2006.08.024
PubMed:View item in PubMed

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