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Synaptic plasticity in the subiculum

Item Type:Review
Title:Synaptic plasticity in the subiculum
Creators Name:Behr, J. and Wozny, C. and Fidzinski, P. and Schmitz, D.
Abstract:The subiculum is the principal target of CA1 pyramidal cells. It functions as a mediator of hippocampal-cortical interaction and has been proposed to play an important role in the encoding and retrieval of long-term memory. The cellular mechanisms of memory formation are thought to include long-term potentiation (LTP) and depression (LTD) of synaptic strength. This review summarizes the contemporary knowledge of LTP and LTD at CA1-subiculum synapses. The observation that the underlying mechanisms of LTP and LTD at CA1-subiculum synapses correlate with the discharge properties of subicular pyramidal cell reveals a novel and intriguing mechanism of cell-specific consolidation of hippocampal output.
Keywords:Subiculum, LTP, LTD, Animals
Source:Progress in Neurobiology
ISSN:0301-0082
Publisher:Elsevier (The Netherlands)
Volume:89
Number:4
Page Range:334-342
Date:10 December 2009
Official Publication:https://doi.org/10.1016/j.pneurobio.2009.09.002
PubMed:View item in PubMed

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