Synaptic plasticity in the subiculum

Item Type:	Review
Title:	Synaptic plasticity in the subiculum
Creators Name:	Behr, J. and Wozny, C. and Fidzinski, P. and Schmitz, D.
Abstract:	The subiculum is the principal target of CA1 pyramidal cells. It functions as a mediator of hippocampal-cortical interaction and has been proposed to play an important role in the encoding and retrieval of long-term memory. The cellular mechanisms of memory formation are thought to include long-term potentiation (LTP) and depression (LTD) of synaptic strength. This review summarizes the contemporary knowledge of LTP and LTD at CA1-subiculum synapses. The observation that the underlying mechanisms of LTP and LTD at CA1-subiculum synapses correlate with the discharge properties of subicular pyramidal cell reveals a novel and intriguing mechanism of cell-specific consolidation of hippocampal output.
Keywords:	Subiculum, LTP, LTD, Animals
Source:	Progress in Neurobiology
ISSN:	0301-0082
Publisher:	Elsevier
Volume:	89
Number:	4
Page Range:	334-342
Date:	10 December 2009
Official Publication:	https://doi.org/10.1016/j.pneurobio.2009.09.002
PubMed:	View item in PubMed

Repository Staff Only: item control page