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Natural spike trains trigger short- and long-lasting dynamics at hippocampal mossy fiber synapses in rodents

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Item Type:Article
Title:Natural spike trains trigger short- and long-lasting dynamics at hippocampal mossy fiber synapses in rodents
Creators Name:Gundlfinger, A. and Breustedt, J. and Sullivan, D. and Schmitz, D.
Abstract:Background: Synapses exhibit strikingly different forms of plasticity over a wide range of time scales, from milliseconds to hours. Studies on synaptic plasticity typically use constant-frequency stimulation to activate synapses, whereas in vivo activity of neurons is irregular. Methodology/Principal Findings: Using extracellular and whole-cell electrophysiological recordings, we have here studied the synaptic responses at hippocampal mossy fiber synapses in vitro to stimulus patterns obtained from in vivo recordings of place cell firing of dentate gyrus granule cells in behaving rodents. We find that synaptic strength is strongly modulated on short- and long-lasting time scales during the presentation of the natural stimulus trains. Conclusions/Significance: We conclude that dynamic short- and long-term synaptic plasticity at the hippocampal mossy fiber synapse plays a prominent role in normal synaptic function.
Keywords:Action Potentials, Dentate Gyrus, Electrophysiology, Hippocampal Mossy Fibers, Neuronal Plasticity, Synapses, Time Factors, Animals, Rats
Source:PLoS ONE
ISSN:1932-6203
Publisher:Public Library of Science (U.S.A.)
Volume:5
Number:4
Page Range:e9961
Date:1 April 2010
Official Publication:https://doi.org/10.1371/journal.pone.0009961
PubMed:View item in PubMed

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