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Cell-type-specific modulation of feedback inhibition by serotonin in the hippocampus

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Item Type:Article
Title:Cell-type-specific modulation of feedback inhibition by serotonin in the hippocampus
Creators Name:Winterer, J. and Stempel, A.V. and Dugladze, T. and Foeldy, C. and Maziashvili, N. and Zivkovic, A.R. and Priller, J. and Soltesz, I. and Gloveli, T. and Schmitz, D.
Abstract:Midbrain raphe nuclei provide strong serotonergic projections to the hippocampus, in which serotonin (5-HT) exerts differential effects mediated by multiple 5-HT receptor subtypes. The functional relevance of this diversity of information processing is poorly understood. Here we show that serotonin via 5-HT(1B) heteroreceptors substantially reduces synaptic excitation of cholecystokinin-expressing interneurons in area CA1 of the rat hippocampus, in contrast to parvalbumin-expressing basket cells. The reduction is input specific, affecting only glutamatergic synaptic transmission originating from CA1 pyramidal cells. As a result, serotonin selectively decreases feedback inhibition via 5-HT(1B) receptor activation and subsequently increases the integration time window for spike generation in CA1 pyramidal cells. Our data imply an important role for serotonergic modulation of GABAergic action in subcortical control of hippocampal output.
Keywords:Cholecystokinin, Glutamic Acid, Hippocampus, Immunohistochemistry, Neural Inhibition, Neural Pathways, Neurons, Patch-Clamp Techniques, Physiological Feedback, Raphe Nuclei, Serotonin, Synaptic Transmission, Animals, Rats, Wistar Rats
Source:Journal of Neuroscience
ISSN:0270-6474
Publisher:Society for Neuroscience (U.S.A.)
Volume:31
Number:23
Page Range:8464-8475
Date:8 June 2011
Official Publication:https://doi.org/10.1523/JNEUROSCI.6382-10.2011
PubMed:View item in PubMed

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