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Segregation of axonal and somatic activity during fast network oscillations

Item Type:Article
Title:Segregation of axonal and somatic activity during fast network oscillations
Creators Name:Dugladze, T. and Schmitz, D. and Whittington, M.A. and Vida, I. and Gloveli, T.
Abstract:In central neurons, information flows from the dendritic surface toward the axon terminals. We found that during in vitro gamma oscillations, ectopic action potentials are generated at high frequency in the distal axon of pyramidal cells (PCs) but do not invade the soma. At the same time, axo-axonic cells (AACs) discharged at a high rate and tonically inhibited the axon initial segment, which can be instrumental in preventing ectopic action potential back-propagation. We found that activation of a single AAC substantially lowered soma invasion by antidromic action potential in postsynaptic PCs. In contrast, activation of soma-inhibiting basket cells had no significant impact. These results demonstrate that AACs can separate axonal from somatic activity and maintain the functional polarization of cortical PCs during network oscillations.
Keywords:Action Potentials, Axons, Electric Stimulation, GABA-A Receptor Antagonists, GABA-A Receptors, gamma-Aminobutyric Acid, Hippocampal CA3 Region, Interneurons, Nerve Net, Neural Inhibition, Patch-Clamp Techniques, Presynaptic Terminals, Pyramidal Cells, Pyridazines, Synapses, Animals, Mice
Source:Science
ISSN:0036-8075
Publisher:American Association for the Advancement of Science (U.S.A.)
Volume:336
Number:6087
Page Range:1458-1461
Date:15 June 2012
Official Publication:https://doi.org/10.1126/science.1222017
PubMed:View item in PubMed

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