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Role of RIM1{alpha} in short- and long-term synaptic plasticity at cerebellar parallel fibres

Official URL:https://doi.org/10.1038/ncomms3392
PubMed:View item in PubMed
Creators Name:Kintscher, M. and Wozny, C. and Johenning, F.W. and Schmitz, D. and Breustedt, J.
Journal Title:Nature Communications
Journal Abbreviation:Nat Commun
Volume:4
Page Range:2392
Date:3 September 2013
Keywords:Biological Transport, Calcium, Calcium Channels, Cerebellum, Electrophysiology, GTP-Binding Proteins, Neuronal Plasticity, Presynaptic Terminals, Protein Isoforms, Purkinje Cells, Synapses, Synaptic Transmission, Animals, Mice
Abstract:The presynaptic terminals of synaptic connections are composed of a complex network of interacting proteins that collectively ensure proper synaptic transmission and plasticity characteristics. The key components of this network are the members of the RIM protein family. Here we show that RIM1{alpha} can influence short-term plasticity at cerebellar parallel-fibre synapses. We demonstrate that the loss of a single RIM isoform, RIM1{alpha}, leads to reduced calcium influx in cerebellar granule cell terminals, decreased release probability and consequently an enhanced short-term facilitation. In contrast, we find that presynaptic long-term plasticity is fully intact in the absence of RIM1{alpha}, arguing against its necessary role in the expression of this important process. Our data argue for a universal role of RIM1{alpha} in setting release probability via interaction with voltage-dependent calcium channels at different connections instead of synapse-specific functions.
ISSN:2041-1723
Publisher:Nature Publishing Group (U.K.)
Item Type:Article

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