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uORFdb - a comprehensive literature database on eukaryotic uORF biology

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Item Type:Article
Title:uORFdb - a comprehensive literature database on eukaryotic uORF biology
Creators Name:Wethmar, K. and Barbosa-Silva, A. and Andrade-Navarro, M.A. and Leutz, A.
Abstract:Approximately half of all human transcripts contain at least one upstream translational initiation site that precedes the main coding sequence (CDS) and gives rise to an upstream open reading frame (uORF). We generated uORFdb, publicly available at http://cbdm.mdc-berlin.de/tools/uorfdb, to serve as a comprehensive literature database on eukaryotic uORF biology. Upstream ORFs affect downstream translation by interfering with the unrestrained progression of ribosomes across the transcript leader sequence. Although the first uORF-related translational activity was observed >30 years ago, and an increasing number of studies link defective uORF-mediated translational control to the development of human diseases, the features that determine uORF-mediated regulation of downstream translation are not well understood. The uORFdb was manually curated from all uORF-related literature listed at the PubMed database. It categorizes individual publications by a variety of denominators including taxon, gene and type of study. Furthermore, the database can be filtered for multiple structural and functional uORF-related properties to allow convenient and targeted access to the complex field of eukaryotic uORF biology.
Keywords:Alternative Splicing, Nucleic Acid Databases, Disease, Genetic Variation, Internet, Nonsense Mediated mRNA Decay, Open Reading Frames, Genetic Promoter Regions, Protein Biosynthesis, RNA Stability, Messenger RNA, Ribosomes, Animals, Mice
Source:Nucleic Acids Research
Publisher:Oxford University Press
Page Range:D60-D67
Date:1 January 2014
Official Publication:https://doi.org/10.1093/nar/gkt952
PubMed:View item in PubMed

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