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Does long-term survival in patients with pancreatic cancer really exist? Results from the CONKO-001 study

Item Type:Article
Title:Does long-term survival in patients with pancreatic cancer really exist? Results from the CONKO-001 study
Creators Name:Sinn, M. and Striefler, J.K. and Sinn, B.V. and Sallmon, D. and Bischoff, S. and Stieler, J.M. and Pelzer, U. and Bahra, M. and Neuhaus, P. and Doerken, B. and Denkert, C. and Riess, H. and Oettle, H.
Abstract:BACKGROUND: Long-term survival (LTS) in patients (pts) with pancreatic cancer is still uncommon, little data is available to identify long-term survivors. The CONKO-001 study, which established gemcitabine after resection as adjuvant therapy, may provide data to answer this question. METHODS: CONKO-001 pts with an overall survival >/=5 years were compared to those who survived <5 years. Central re-evaluation of primary histology was performed. Univariate analysis with the chi(2) -test identified qualifying factors. Logistic regression was used to investigate the influence of these covariates on LTS. RESULTS: Of the evaluable 354 CONKO-001 pts, 54 (15%) with an overall survival >/=5 years were identified. It was possible to obtain tumor specimens of 39 pts (72%). Histological re-evaluation confirmed adenocarcinoma in 38 pts, 1 showed a high-grade neuroendocrine tumor. Univariate analysis for all 53 LTS pts with adenocarcinoma compared to the remaining 300 non-LTS pts revealed as relevant active treatment, tumor grading, tumor size, lymph nodes. No significance could be demonstrated for resection margin, sex, age, Karnofsky performance status, CA 19-9 at study entry. In multivariate analysis, tumor grading, active treatment, tumor size, lymph node involvement were independent prognostic factors for LTS. CONCLUSION: Long-term survival can be achieved in adenocarcinoma of the pancreas.
Keywords:Rate of Cure, Adjuvant Therapy, Gemcitabine
Source:Journal of Surgical Oncology
ISSN:0022-4790
Publisher:Wiley-Blackwell (U.S.A.)
Volume:108
Number:6
Page Range:398-402
Date:November 2013
Official Publication:https://doi.org/10.1002/jso.23409
PubMed:View item in PubMed

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