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Mutually exclusive signaling signatures define the hepatic and pancreatic progenitor cell lineage divergence

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Official URL:https://doi.org/10.1101/gad.220244.113
PubMed:View item in PubMed
Creators Name:Rodriguez-Seguel, E. and Mah, N. and Naumann, H. and Pongrac, I.M. and Cerda-Esteban, N. and Fontaine, J.F. and Wang, Y. and Chen, W. and Andrade-Navarro, M.A. and Spagnoli, F.M.
Journal Title:Genes & Development
Journal Abbreviation:Genes Dev
Page Range:1932-1946
Date:1 September 2013
Keywords:Liver, Pancreas, RNA-seq, Wnt Signaling, Animals, Mice, Xenopus
Abstract:Understanding how distinct cell types arise from multipotent progenitor cells is a major quest in stem cell biology. The liver and pancreas share many aspects of their early development and possibly originate from a common progenitor. However, how liver and pancreas cells diverge from a common endoderm progenitor population and adopt specific fates remains elusive. Using RNA sequencing (RNA-seq), we defined the molecular identity of liver and pancreas progenitors that were isolated from the mouse embryo at two time points, spanning the period when the lineage decision is made. The integration of temporal and spatial gene expression profiles unveiled mutually exclusive signaling signatures in hepatic and pancreatic progenitors. Importantly, we identified the noncanonical Wnt pathway as a potential developmental regulator of this fate decision and capable of inducing the pancreas program in endoderm and liver cells. Our study offers an unprecedented view of gene expression programs in liver and pancreas progenitors and forms the basis for formulating lineage-reprogramming strategies to convert adult hepatic cells into pancreatic cells.
Publisher:Cold Spring Harbor Laboratory Press (U.S.A.)
Item Type:Article

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