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Transcription factories: quantitative studies of nanostructures in the mammalian nucleus

Item Type:Article
Title:Transcription factories: quantitative studies of nanostructures in the mammalian nucleus
Creators Name:Martin, S. and Pombo, A.
Abstract:Transcription by the three nuclear RNA polymerases is carried out in transcription factories. This conclusion has been drawn from estimates of the total number of nascent transcripts or active polymerase molecules and the number of transcription sites within a cell. Here we summarise the variety of methods used to determine these parameters, discuss their associated problems and outline future prospects.
Keywords:Nascent Transcripts, Nucleolus, RNA Polymerase, Transcription Sites
Source:Chromosome Research
ISSN:0967-3849
Publisher:Kluwer Academic Publishers (The Netherlands)
Volume:11
Number:5
Page Range:461-470
Date:1 July 2003
Official Publication:https://doi.org/10.1023/A:1024926710797
PubMed:View item in PubMed

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