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Gene positioning

Item Type:Article
Title:Gene positioning
Creators Name:Ferrai, C. and de Castro, I.J. and Lavitas, L. and Chotalia, M. and Pombo, A.
Abstract:Eukaryotic gene expression is an intricate multistep process, regulated within the cell nucleus through the activation or repression of RNA synthesis, processing, cytoplasmic export, and translation into protein. The major regulators of gene expression are chromatin remodeling and transcription machineries that are locally recruited to genes. However, enzymatic activities that act on genes are not ubiquitously distributed throughout the nucleoplasm, but limited to specific and spatially defined foci that promote preferred higher-order chromatin arrangements. The positioning of genes within the nuclear landscape relative to specific functional landmarks plays an important role in gene regulation and disease.
Keywords:Chromatin, Gene Expression Regulation, Gene Order, Genetic Predisposition to Disease, Inborn Genetic Diseases
Source:Cold Spring Harbor Perspectives in Biology
Publisher:Cold Spring Harbor Laboratory Press
Page Range:a000588
Date:June 2010
Official Publication:https://doi.org/10.1101/cshperspect.a000588
PubMed:View item in PubMed

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