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Biomarker validation of a cued recall memory deficit in prodromal Alzheimer disease

Item Type:Article
Title:Biomarker validation of a cued recall memory deficit in prodromal Alzheimer disease
Creators Name:Wagner, M. and Wolf, S. and Reischies, F.M. and Daerr, M. and Wolfsgruber, S. and Jessen, F. and Popp, J. and Maier, W. and Huell, M. and Froelich, L. and Hampel, H. and Perneczky, R. and Peters, O. and Jahn, H. and Luckhaus, C. and Gertz, H.J. and Schroeder, J. and Pantel, J. and Lewczuk, P. and Kornhuber, J. and Wiltfang, J.
Abstract:Objective: To compare cued recall measures with other memory and nonmemory tests regarding their association with a biomarker profile indicative of Alzheimer disease (AD) in CSF among patients with mild cognitive impairment (MCI). Methods: Data were obtained by the German Dementia Competence Network. A total of 185 memory clinic patients fulfilling broad criteria for MCI (1 SD deficit in memory tests or in nonmemory tests) were assessed with an extended neuropsychological battery, which included the Free and Cued Selective Reminding Test (FCSRT), the word list learning task from the Consortium to Establish a Registry for Alzheimer's Disease neuropsychological battery (CERAD-NP), and the Logical Memory (LM) paragraph recall test from the Wechsler Memory Scale-Revised. CSF was obtained from all patients. Results: A total of 74 out of 185 subjects with MCI (40%) had a CSF profile consistent with AD (Aβ(1-42)/tau ratio; CSF AD+ group). FCSRT measures reflecting both free and cued recall discriminated best between CSF AD+ and CSF AD- patients, and significantly improved CSF AD classification accuracy, as compared with CERAD delayed recall and LM delayed recall. Conclusions: Cued recall deficits are most closely associated with CSF biomarkers indicative of AD in subjects with MCI. This novel finding complements results from prospective clinical studies and provides further empirical support for cued recall as a specific indicator of prodromal AD, in line with recently proposed research criteria.
Keywords:Alzheimer Disease, Amyloid Beta-Peptides, Cues, Disease Progression, Mental Recall, Mild Cognitive Impairment, Neuropsychological Tests, Peptide Fragments, Tau Proteins
Publisher:American Academy of Neurology
Page Range:379-386
Date:7 February 2012
Official Publication:https://doi.org/10.1212/WNL.0b013e318245f447
PubMed:View item in PubMed

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