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Impact of beta-amyloid-specific florbetaben PET imaging on confidence in early diagnosis of Alzheimer's disease

Item Type:Article
Title:Impact of beta-amyloid-specific florbetaben PET imaging on confidence in early diagnosis of Alzheimer's disease
Creators Name:Schipke, C.G. and Peters, O. and Heuser, I. and Grimmer, T. and Sabbagh, M.N. and Sabri, O. and Hock, C. and Kunz, M. and Kuhlmann, J. and Reininger, C. and Blankenburg, M.
Abstract:Background: Early diagnosis of Alzheimer's disease (AD) may be corroborated by imaging of beta-amyloid plaques using positron emission tomography (PET). Here, we performed an add-on questionnaire study to evaluate the relevance of florbetaben imaging (BAY 949172) in diagnosis and consecutive management of probable AD patients. Methods: AD patients with a clinical diagnosis in accordance with the NINCDS-ADRDA criteria or controls were imaged using florbetaben. Referring physicians were asked on a voluntary basis about their confidence in initial diagnosis, significance of PET imaging results, and their anticipated consequences for future patient care. Results: 121 questionnaires for probable AD patients and 80 questionnaires for controls were evaluated. In 18% of patients who had initially received the diagnosis of probable AD, PET scans were rated negative, whereas in controls 18% of scans were positive. An increase in confidence in the initial diagnosis was frequently reported (80%). Imaging results had a significant impact on the intended patient care, as judged by the referring physicians; this was most prominent in those patients with a contradicting scan and/or a low confidence in the initial diagnosis. Conclusion: Florbetaben amyloid imaging increases the overall confidence in diagnosis of AD and may frequently influence clinical decisions and patient management.
Keywords:Alzheimer’s Disease, Beta-Amyloid Plaques, Florbetaben, Amyloid Imaging
Source:Dementia and Geriatric Cognitive Disorders
Page Range:416-422
Date:August 2012
Additional Information:Erratum in: Dement Geriatr Cogn Disord 33(6): 416-422.
Official Publication:https://doi.org/10.1159/000339367
PubMed:View item in PubMed

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