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Association of N-acetylaspartate and cerebrospinal fluid Aβ42 in dementia

Item Type:Article
Title:Association of N-acetylaspartate and cerebrospinal fluid Aβ42 in dementia
Creators Name:Jessen, F. and Lewczuk, P. and Guer, O. and Block, W. and Ende, G. and Froelich, L. and Hammen, T. and Arlt, S. and Kornhuber, J. and Kucinski, T. and Popp, J. and Peters, O. and Maier, W. and Traeber, F. and Wiltfang, J.
Abstract:The interplay of amyloid and mitochondrial function is considered crucial in the pathophysiology of Alzheimer's disease (AD). We tested the association of the putative marker of mitochondrial function N-acetylaspartate (NAA) as measured by proton magnetic resonance spectroscopy within the medial temporal lobe and cerebrospinal fluid amyoid-β42 (A{beta}42), total Tau and pTau181. 109 patients were recruited in a multicenter study (40 mild AD patients, 14 non-AD dementia patients, 29 mild cognitive impairment (MCI) AD-type patients, 26 MCI of non-AD type patients). NAA correlated with A{beta}42 within the AD group. Since the NAA concentration is coupled to neuronal mitochondrial function, the correlation between NAA and Aβ42 may reflect the interaction between disrupted mitochondrial pathways and amyloid production.
Keywords:Alzheimer's Disease, Amyloid-{beta}\(_{\rm{42}}\), N-Acetylaspartate, Medial Temporal Lobe, Mitochondria, Proton MR Spectrocopy
Source:Journal of Alzheimer's Disease
Publisher:IOS Press
Page Range:393-399
Official Publication:https://doi.org/10.3233/JAD-2011-110398
PubMed:View item in PubMed

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