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| Item Type: | Article |
|---|---|
| Title: | Soluble amyloid precursor proteins in the cerebrospinal fluid as novel potential biomarkers of Alzheimer's disease: a multicenter study |
| Creators Name: | Lewczuk, P., Kamrowski-Kruck, H., Peters, O., Heuser, I., Jessen, F., Popp, J., Buerger, K., Hampel, H., Froelich, L., Wolf, S., Prinz, B., Jahn, H., Luckhaus, C., Perneczky, R., Huell, M., Schroeder, J., Kessler, H., Pantel, J., Gertz, H.J., Klafki, H.W., Koelsch, H., Reulbach, U., Esselmann, H., Maler, J.M., Bibl, M., Kornhuber, J. and Wiltfang, J. |
| Abstract: | In this report, we present the results of a multicenter study to test analytic and diagnostic performance of soluble forms of amyloid precursor proteins {alpha} and {beta} (sAPP{alpha} and sAPP{beta}) in the cerebrospinal fluid (CSF) of patients with different forms of dementing conditions. CSF samples were collected from 188 patients with early dementia (mini-mental state examination >or=20 in majority of cases) and mild cognitive impairment (MCI) in 12 gerontopsychiatric centers, and the clinical diagnoses were supported by neurochemical dementia diagnostic (NDD) tools: CSF amyloid{beta} peptides, Tau and phospho-Tau. sAPP{alpha} and sAPP{beta} were measured with multiplexing method based on electrochemiluminescence. sAPP{alpha} and sAPP{beta} CSF concentrations correlated with each other with very high correlation ratio (R=0.96, P<0.001). We observed highly significantly increased sAPP{alpha} and sAPP{beta} CSF concentrations in patients with NDD characteristic for Alzheimer's disease (AD) compared to those with NDD negative results. sAPP{alpha} and sAPP{beta} highly significantly separated patients with AD, whose diagnosis was supported by NDD findings (sAPP{alpha}: cutoff, 117.4 ng ml(-1), sensitivity, 68%, specificity, 85%, P<0.001; sAPP{beta}: cutoff, 181.8 ng ml(-1), sensitivity, 75%, specificity, 85%, P<0.001), from the patients clinically assessed as having other dementias and supported by NDD untypical for AD. We conclude sAPP{alpha} and sAPP{beta} might be regarded as novel promising biomarkers supporting the clinical diagnosis of AD. |
| Keywords: | Dementia, Alzheimer Disease, Amyloid{beta}, Amyloid Precursor Protein, Multiplexing, Cerebrospinal Fluid |
| Source: | Molecular Psychiatry |
| ISSN: | 1359-4184 |
| Publisher: | Nature Publishing Group |
| Volume: | 15 |
| Number: | 2 |
| Page Range: | 138-145 |
| Date: | February 2010 |
| Official Publication: | https://doi.org/10.1038/mp.2008.84 |
| PubMed: | View item in PubMed |
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