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Amyloidβ peptide ratio 42/40 but not Aβ42 correlates with phospho-Tau in patients with low- and high-CSF Aβ40 load

Item Type:Article
Title:Amyloidβ peptide ratio 42/40 but not Aβ42 correlates with phospho-Tau in patients with low- and high-CSF Aβ40 load
Creators Name:Wiltfang, J. and Esselmann, H. and Bibl, M. and Huell, M. and Hampel, H. and Kessler, H. and Froelich, L. and Schroeder, J. and Peters, O. and Jessen, F. and Luckhaus, C. and Perneczky, R. and Jahn, H. and Fiszer, M. and Maler, J.M. and Zimmermann, R. and Bruckmoser, R. and Kornhuber, J. and Lewczuk, P.
Abstract:Neurochemical dementia diagnostics (NDD) can significantly improve the clinically based categorization of patients with early dementia disorders, and the cerebrospinal fluid (CSF) concentrations of amyloid beta peptides ending at the amino acid position of 42 (A{beta}x-42 and A{beta}1-42) are widely accepted biomarkers of Alzheimer's disease (AD). However, in subjects with constitutively high- or low-CSF concentrations of total A{beta} peptides (tA{beta}), the NDD interpretation might lead to erroneous conclusions as these biomarkers seem to correlate better with the total A{beta} load than with the pathological status of a given patient in such cases. In this multicenter study, we found significantly increased CSF concentrations of phosphorylated Tau (pTau181) and total Tau in the group of subjects with high CSF A{beta}x-40 concentrations and decreased A{beta}x-42/x-40 concentration ratio compared with the group of subjects with low CSF A{beta}x-40 and normal A{beta} ratio (p<0.001 in both cases). Furthermore, we observed significantly decreased A{beta} ratio (p<0.01) in the group of subjects with APOE epsilon 4 allele compared with the group of subjects without this allele. Surprisingly, patients with low-A{beta}x-40 and the decreased A beta ratio characterized with decreased pTau181 (p<0.05), and unaltered total Tau compared with the subjects with high A{beta}x-40 and the A{beta}ratio in the normal range. We conclude that the amyloid{beta} concentration ratio should replace the 'raw' concentrations of corresponding A{beta} peptides to improve reliability of the neurochemical dementia diagnosis.
Keywords:Amyloid {beta}, Biomarkers, Cerebrospinal Fluid, Dementias
Source:Journal of Neurochemistry
ISSN:0022-3042
Publisher:Blackwell Publishing (U.K.)
Volume:101
Number:4
Page Range:1053-1059
Date:May 2007
Official Publication:https://doi.org/10.1111/j.1471-4159.2006.04404.x
PubMed:View item in PubMed

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