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Complexity of chromatin folding is captured by the strings and binders switch model

Item Type:Article
Title:Complexity of chromatin folding is captured by the strings and binders switch model
Creators Name:Barbieri, M. and Chotalia, M. and Fraser, J. and Lavitas, L.M. and Dostie, J. and Pombo, A. and Nicodemi, M.
Abstract:Chromatin has a complex spatial organization in the cell nucleus that serves vital functional purposes. A variety of chromatin folding conformations has been detected by single-cell imaging and chromosome conformation capture-based approaches. However, a unified quantitative framework describing spatial chromatin organization is still lacking. Here, we explore the "strings and binders switch" model to explain the origin and variety of chromatin behaviors that coexist and dynamically change within living cells. This simple polymer model recapitulates the scaling properties of chromatin folding reported experimentally in different cellular systems, the fractal state of chromatin, the processes of domain formation, and looping out. Additionally, the strings and binders switch model reproduces the recently proposed "fractal-globule" model, but only as one of many possible transient conformations.
Keywords:Genome Organization, Genome Architecture, Long-Range Chromatin Interactions, Fluorescence In Situ Hybridization, Monte Carlo Simulations
Source:Proceedings of the National Academy of Sciences of the United States of America
Publisher:National Academy of Sciences
Page Range:16173-16178
Date:2 October 2012
Official Publication:https://doi.org/10.1073/pnas.1204799109
PubMed:View item in PubMed

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