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A model of the large-scale organization of chromatin

Item Type:Article
Title:A model of the large-scale organization of chromatin
Creators Name:Barbieri, M. and Chotalia, M. and Fraser, J. and Lavitas, L.M. and Dostie, J. and Pombo, A. and Nicodemi, M.
Abstract:In the cell nucleus, chromosomes have a complex spatial organization, spanning several length scales, which serves vital functional purposes. It is unknown, however, how their three-dimensional architecture is orchestrated. In the present article, we review the application of a model based on classical polymer physics, the strings and binders switch model, to explain the molecular mechanisms of chromatin self-organization. We explore the scenario where chromatin architecture is shaped and regulated by the interactions of chromosomes with diffusing DNA-binding factors via thermodynamics mechanisms and compare it with available experimental data.
Keywords:Chromatin Organization, Chromosome Capture, Polymer Physics, Self-Organization, Strings and Binders Switch Model, Thermodynamics, Animals
Source:Biochemical Society Transactions
Publisher:Portland Press
Page Range:508-512
Date:April 2013
Official Publication:https://doi.org/10.1042/BST20120238
PubMed:View item in PubMed

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