A model of the large-scale organization of chromatin

Item Type:	Article
Title:	A model of the large-scale organization of chromatin
Creators Name:	Barbieri, M. and Chotalia, M. and Fraser, J. and Lavitas, L.M. and Dostie, J. and Pombo, A. and Nicodemi, M.
Abstract:	In the cell nucleus, chromosomes have a complex spatial organization, spanning several length scales, which serves vital functional purposes. It is unknown, however, how their three-dimensional architecture is orchestrated. In the present article, we review the application of a model based on classical polymer physics, the strings and binders switch model, to explain the molecular mechanisms of chromatin self-organization. We explore the scenario where chromatin architecture is shaped and regulated by the interactions of chromosomes with diffusing DNA-binding factors via thermodynamics mechanisms and compare it with available experimental data.
Keywords:	Chromatin Organization, Chromosome Capture, Polymer Physics, Self-Organization, Strings and Binders Switch Model, Thermodynamics, Animals
Source:	Biochemical Society Transactions
ISSN:	0300-5127
Publisher:	Portland Press
Volume:	41
Number:	2
Page Range:	508-512
Date:	April 2013
Official Publication:	https://doi.org/10.1042/BST20120238
PubMed:	View item in PubMed

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