Higher relative risk for multiple sclerosis in a pediatric and adolescent diabetes population: analysis from DPV data base

Item Type:	Article
Title:	Higher relative risk for multiple sclerosis in a pediatric and adolescent diabetes population: analysis from DPV data base
Creators Name:	Bechtold, S. and Blaschek, A. and Raile, K. and Dost, A. and Freiberg, C. and Askenas, M. and Froehlich-Reiterer, E. and Molz, E. and Holl, R.W.
Abstract:	Objective: Type 1 diabetes and multiple sclerosis (MS) are typical autoimmune diseases in children and young adults. We assessed the co-occurrence of type 1 diabetes and MS by estimating the relative risk for MS in a pediatric and adolescent diabetes population and looked for possible influencing factors. Research Design and Methods: Within the DPV-Wiss-project, from January 1995 to October 2012, data of 56,653 patients with type 1 diabetes were collected in 248 centers in Germany and Austria. Published data on German and Mid-European MS prevalence were taken for comparison. Multivariable regression analysis was used to identify confounders for co-occurrence of type 1 diabetes and MS. Results: Relative risk for MS in type 1 diabetes was estimated at 3.35 to 4.79 (95% CI: 1.56 to 7.21 and 2.01 to 11.39, respectively). As influencing factors on MS incidence within the DPV database could be identified immigration status in all (p<0.05) and thyroid antibodies in males only (p= 0.05). The month of birth pattern was higher during the spring and summer months in the type 1 diabetes with MS in comparison to the type 1 diabetes population. Conclusion: The present cohort study demonstrates a higher risk of co-occurrence of MS in a pediatric and adolescent diabetes population. Immigration status and thyroid antibodies in males were independent risk indicators for incidental rate of MS. Diabetic patients born during spring and summer had a higher risk to develop MS. We suggest that environmental factors modulate the individual's risk for the co-occurrence of both diseases.
Keywords:	Age of Onset, Austria, Cohort Studies, Type 1 Diabetes Mellitus, Emigration and Immigration, Germany, Incidence, Multiple Sclerosis, Prevalence, Regression Analysis, Risk Factors, Seasons, Sex Factors, Young Adult
Source:	Diabetes Care
ISSN:	0149-5992
Publisher:	American Diabetes Association
Volume:	37
Number:	1
Page Range:	96-101
Date:	January 2014
Official Publication:	https://doi.org/10.2337/dc13-1414
PubMed:	View item in PubMed

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