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| Item Type: | Article |
|---|---|
| Title: | Sustained-input switches for transcription factors and microRNAs are central building blocks of eukaryotic gene circuits |
| Creators Name: | Megraw, M. and Mukherjee, S. and Ohler, U. |
| Abstract: | WaRSwap is a randomization algorithm that for the first time provides a practical network motif discovery method for large multi-layer networks, for example those that include transcription factors, microRNAs, and non-regulatory protein coding genes. The algorithm is applicable to systems with tens of thousands of genes, while accounting for critical aspects of biological networks, including self-loops, large hubs, and target rearrangements. We validate WaRSwap on a newly inferred regulatory network from Arabidopsis thaliana, and compare outcomes on published Drosophila and human networks. Specifically, sustained input switches are among the few over-represented circuits across this diverse set of eukaryotes. |
| Keywords: | Gene Regulation, microRNA, Network Motif, Transcription Factor, Animals, Drosophila Melanogaster |
| Source: | Genome Biology |
| ISSN: | 1465-6906 |
| Publisher: | BioMed Central |
| Volume: | 14 |
| Number: | 8 |
| Page Range: | R85 |
| Date: | 23 August 2013 |
| Official Publication: | https://doi.org/10.1186/gb-2013-14-8-r85 |
| PubMed: | View item in PubMed |
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