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Expression profiling of autophagy associated genes in placentas of preeclampsia

Item Type:Article
Title:Expression profiling of autophagy associated genes in placentas of preeclampsia
Creators Name:Goldman-Wohl, D. and Cesla, T. and Smith, Y. and Greenfield, C. and Dechend, R. and Staff, A.C. and Sugulle, M. and Weedon-Fekjær, M.S. and Johnsen, G.M. and Yagel, S. and Haimov-Kochman, R.
Abstract:Autophagy, a mechanism of cell survival during times of stress, may be active in normal placental maintenance, cushioning the fetus from strain during fluctuations in nutrient availability. Moreover, in cases of placental insufficiency, often present in preeclampsia, autophagy may be defective. We used published microarray datasets to analyze differential expression of autophagy pathway genes. No statistically significant difference in autophagy associated gene expression was found in preeclamptic vs. normal placenta samples. Thus although preeclampsia displays many of the features suggestive of altered autophagy, impaired placental autophagy as a cause of preeclampsia is not supported by whole placental tissue differential expression profiling.
Keywords:Preeclampsia, Placenta, Autophagy, Differential Expression Profiling
Page Range:959-962
Date:October 2013
Official Publication:https://doi.org/10.1016/j.placenta.2013.07.069
PubMed:View item in PubMed

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