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Inverse relation of E-cadherin and autocrine motility factor receptor expression as a prognostic factor in patients with bladder carcinomas

Item Type:Article
Title:Inverse relation of E-cadherin and autocrine motility factor receptor expression as a prognostic factor in patients with bladder carcinomas
Creators Name:Otto, T. and Birchmeier, W. and Schmidt, U. and Hinke, A. and Schipper, J. and Ruebben, H. and Raz, A.
Abstract:Down-regulation of E-cadherin, an intercellular adhesion molecule, and up-regulation of autocrine motility factor receptor (gp78) expressions have been shown to play a role in tumor cell invasion and metastasis. Monoclonal antibodies against E-cadherin and gp78 were used to stain serial snap-frozen sections of 12 normal bladder and 83 bladder carcinoma specimens (27 noninvasive, 53 invasive, and 3 metastases). In normal urothelium, E-cadherin is expressed while gp78 is not. Positive expression of E-cadherin and negative expression of gp78 were found to be associated with a low risk of clinical progression in the superficial bladder carcinoma patient group. While reduction in E-cadherin concomitantly with an increase in gp78 expression was associated with poor prognosis, 71% of the patients (n = 30) underwent rapid cancer progression, and 32% of the patients died of cancer-related disease at a median of 2 years after initial diagnosis. Thus, it is suggested that reduction of E-cadherin expression associated with an increase in the level of gp78 in bladder cancers may define a high risk group of patients. The dual use of these two antigens may improve early diagnosis of high risk bladder cancer patients and influence treatment decisions.
Keywords:Biological Markers, Cadherins, Cytokine Receptors, Evaluation Studies as Topic, Follow-Up Studies, Neoplasm Staging, Prognosis, Retrospective Studies, Ubiquitin-Protein Ligases, Urinary Bladder Neoplasms
Source:Cancer Research
ISSN:0008-5472
Publisher:American Association for Cancer Research (U.S.A.)
Volume:54
Number:12
Page Range:3120-3123
Date:15 June 1994
Official Publication:http://cancerres.aacrjournals.org/content/54/12/3120.abstract
PubMed:View item in PubMed

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