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Cellular and molecular basis of cerebellar development

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Item Type:Review
Title:Cellular and molecular basis of cerebellar development
Creators Name:Martinez, S. and Andreu, A. and Mecklenburg, N. and Echevarria, D.
Abstract:Historically, the molecular and cellular mechanisms of cerebellar development were investigated through structural descriptions and studying spontaneous mutations in animal models and humans. Advances in experimental embryology, genetic engineering, and neuroimaging techniques render today the possibility to approach the analysis of molecular mechanisms underlying histogenesis and morphogenesis of the cerebellum by experimental designs. Several genes and molecules were identified to be involved in the cerebellar plate regionalization, specification, and differentiation of cerebellar neurons, as well as the establishment of cellular migratory routes and the subsequent neuronal connectivity. Indeed, pattern formation of the cerebellum requires the adequate orchestration of both key morphogenetic signals, arising from distinct brain regions, and local expression of specific transcription factors. Thus, the present review wants to revisit and discuss these morphogenetic and molecular mechanisms taking place during cerebellar development in order to understand causal processes regulating cerebellar cytoarchitecture, its highly topographically ordered circuitry and its role in brain function.
Keywords:Rostral Hindbrain, Caudal Mesencephalon, Cerebellum, Isthmus, Isthmic Organizer, Isthmic Constriction, Fgf8, Morphogenesis
Source:Frontiers in Neuroanatomy
ISSN:1662-5129
Publisher:Frontiers Media SA
Volume:7
Page Range:18
Date:26 June 2013
Official Publication:https://doi.org/10.3389/fnana.2013.00018
PubMed:View item in PubMed

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