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Functional and structural brain changes in anti-N-methyl-D-aspartate receptor encephalitis

Item Type:Article
Title:Functional and structural brain changes in anti-N-methyl-D-aspartate receptor encephalitis
Creators Name:Finke, C. and Kopp, U.A. and Scheel, M. and Pech, L.M. and Soemmer, C. and Schlichting, J. and Leypoldt, F. and Brandt, A.U. and Wuerfel, J. and Probst, C. and Ploner, C.J. and Prüss, H. and Paul, F.
Abstract:OBJECTIVE: Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is an autoimmune encephalitis with a characteristic neuropsychiatric syndrome and severe and prolonged clinical courses. In contrast, standard clinical magnetic resonance imaging (MRI) remains normal in the majority of patients. Here, we investigated structural and functional brain changes in a cohort of patients with anti-NMDAR encephalitis. METHODS: Twenty-four patients with established diagnosis of anti-NMDAR encephalitis and age- and gender-matched controls underwent neuropsychological testing and multimodal MRI, including T1w/T2w structural imaging, analysis of resting state functional connectivity, analysis of white matter using diffusion tensor imaging, and analysis of gray matter using voxel-based morphometry. RESULTS: Patients showed significantly reduced functional connectivity of the left and right hippocampus with the anterior default mode network. Connectivity of both hippocampi predicted memory performance in patients. Diffusion tensor imaging revealed extensive white matter changes, which were most prominent in the cingulum and which correlated with disease severity. In contrast, no differences in T1w/T2w structural imaging and gray matter morphology were observed between patients and controls. INTERPRETATION: Anti-NMDAR encephalitis is associated with characteristic alterations of functional connectivity and widespread changes of white matter integrity despite normal findings in routine clinical MRI. These results may help to explain the clinicoradiological paradox in anti-NMDAR encephalitis and advance the pathophysiological understanding of the disease. Correlation of imaging abnormalities with disease symptoms and severity suggests that these changes play an important role in the symptomatology of anti-NMDAR encephalitis.
Keywords:Anti-N-Methyl-D-Aspartate Receptor Encephalitis, Functional Neuroimaging, Hippocampus, Leukoencephalopathies, Magnetic Resonance Imaging, Nerve Net, Neuropsychological Tests, Severity of Illness Index
Source:Annals of Neurology
ISSN:0364-5134
Publisher:Wiley (U.S.A.)
Volume:74
Number:2
Page Range:284-296
Date:August 2013
Official Publication:https://doi.org/10.1002/ana.23932
PubMed:View item in PubMed

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