Helmholtz Gemeinschaft

Search
Browse
Statistics
Feeds

Hacking cell differentiation: transcriptional rerouting in reprogramming, lineage infidelity and metaplasia

[img] PDF - Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader
583kB

Item Type:Review
Title:Hacking cell differentiation: transcriptional rerouting in reprogramming, lineage infidelity and metaplasia
Creators Name:Regalo, G. and Leutz, A.
Abstract:Initiating neoplastic cell transformation events are of paramount importance for the comprehension of regeneration and vanguard oncogenic processes but are difficult to characterize and frequently clinically overlooked. In epithelia, pre-neoplastic transformation stages are often distinguished by the appearance of phenotypic features of another differentiated tissue, termed metaplasia. In haemato/lymphopoietic malignancies, cell lineage ambiguity is increasingly recorded. Both, metaplasia and biphenotypic leukaemia/lymphoma represent examples of dysregulated cell differentiation that reflect a history of trans-differentiation and/or epigenetic reprogramming. Here we compare the similarity between molecular events of experimental cell trans-differentiation as an emerging therapeutic concept, with lineage confusion, as in metaplasia and dysplasia forecasting tumour development.
Keywords:Carcinogenesis, Haematopoiesis, Metaplasia, Transcription Factor, Trans-Differentiation, Animals, Mice
Source:EMBO Molecular Medicine
ISSN:1757-4676
Publisher:Wiley-Blackwell (Germany)
Volume:5
Number:8
Page Range:1154-1164
Date:August 2013
Official Publication:https://doi.org/10.1002/emmm.201302834
PubMed:View item in PubMed

Repository Staff Only: item control page

Downloads

Downloads per month over past year

Open Access
MDC Library