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Activating autoantibodies and cardiovascular disease

Item Type:Review
Title:Activating autoantibodies and cardiovascular disease
Creators Name:Luft, F.C.
Abstract:Stimulating antibodies against G-protein-coupled receptors, including the {beta}1- and {beta}2-adrenergic receptors, the {alpha}1-adrenergic receptor, and the angiotensin II AT1 receptor, have been described, as well as activating antibodies directed at the platelet-derived growth factor receptor tyrosine kinase. Their existence and actions appear to be established. Lacking are mechanistic studies of receptor activation and translational studies to document receptor-stimulating antibodies as worthwhile therapeutic targets.
Keywords:Amino Acid Sequence, Autoantibodies, beta Adrenergic Receptors, Cardiovascular Diseases, Molecular Sequence Data, Translational Medical Research, Type 1 Angiotensin Receptor
Source:Physiology
ISSN:1548-9213
Publisher:American Physiological Society (U.S.A.)
Volume:28
Number:4
Page Range:254-261
Date:July 2013
Official Publication:https://doi.org/10.1152/physiol.00014.2013
PubMed:View item in PubMed

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