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4D flow magnetic resonance imaging in bicuspid aortic valve disease demonstrates altered distribution of aortic blood flow helicity

Item Type:Article
Title:4D flow magnetic resonance imaging in bicuspid aortic valve disease demonstrates altered distribution of aortic blood flow helicity
Creators Name:Lorenz, R. and Bock, J. and Barker, A.J. and von Knobelsdorff-Brenkenhoff, F. and Wallis, W. and Korvink, J.G. and Bissell, M.M. and Schulz-Menger, J. and Markl, M.
Abstract:PURPOSE: Changes in aortic geometry or presence of aortic valve (AoV) disease can result in substantially altered aortic hemodynamics. Dilatation of the ascending aorta or AoV abnormalities can result in an increase in helical flow. METHODS: 4D flow magnetic resonance imaging was used to test the feasibility of quantitative helicity analysis using equidistantly distributed 2D planes along the entire aorta. The evaluation of the method included three parts: (1) the quantification of helicity in 12 healthy subjects, (2) an evaluation of observer variability and test-retest reliability, and (3) the quantification of helical flow in 16 patients with congenitally altered bicuspid AoVs. RESULTS: Helicity quantification in healthy subjects revealed consistent directions of flow rotation along the entire aorta with high clockwise helicity in the aortic arch and an opposite rotation sense in the ascending and descending aorta. The results demonstrated good scan-rescan and inter- and intraobserver agreement of the helicity parameters. Helicity quantification in patients revealed a significant increase in absolute peak relative helicity during systole and a considerably greater heterogeneous distribution of mean helicity in the aorta. CONCLUSION: The method has the potential to serve as a reference distribution for comparisons of helical flow between healthy subjects and patients or between different patient groups.
Keywords:Blood Flow Helicity, Helicity Quantification, Aorta, Aortic Valve Disease, Bicuspid Aortic Valve
Source:Magnetic Resonance in Medicine
ISSN:0740-3194
Publisher:Wiley (U.S.A.)
Volume:71
Number:4
Page Range:1542-1553
Date:April 2014
Official Publication:https://doi.org/10.1002/mrm.24802
PubMed:View item in PubMed

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