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Combined sequence-based and genetic mapping analysis of complex traits in outbred rats

Item Type:Article
Title:Combined sequence-based and genetic mapping analysis of complex traits in outbred rats
Creators Name:Baud, A. and Hermsen, R. and Guryev, V. and Stridh, P. and Graham, D. and McBride, M.W. and Foroud, T. and Calderari, S. and Diez, M. and Ockinger, J. and Beyeen, A.D. and Gillett, A. and Abdelmagid, N. and Guerreiro-Cacais, A.O. and Jagodic, M. and Tuncel, J. and Norin, U. and Beattie, E. and Huynh, N. and Miller, W.H. and Koller, D.L. and Alam, I. and Falak, S. and Osborne-Pellegrin, M. and Martinez-Membrives, E. and Canete, T. and Blazquez, G. and Vicens-Costa, E. and Mont-Cardona, C. and Diaz-Moran, S. and Tobena, A. and Hummel, O. and Zelenika, D. and Saar, K. and Patone, G. and Bauerfeind, A. and Bihoreau, M.T. and Heinig, M. and Lee, Y.A. and Rintisch, C. and Schulz, H. and Wheeler, D.A. and Worley, K.C. and Muzny, D.M. and Gibbs, R.A. and Lathrop, M. and Lansu, N. and Toonen, P. and Ruzius, F.P. and de Bruijn, E. and Hauser, H. and Adams, D.J. and Keane, T. and Atanur, S.S. and Aitman, T.J. and Flicek, P. and Malinauskas, T. and Jones, E.Y. and Ekman, D. and Lopez-Aumatell, R. and Dominiczak, A.F. and Johannesson, M. and Holmdahl, R. and Olsson, T. and Gauguier, D. and Hubner, N. and Fernandez-Teruel, A. and Cuppen, E. and Mott, R. and Flint, J.
Abstract:Genetic mapping on fully sequenced individuals is transforming understanding of the relationship between molecular variation and variation in complex traits. Here we report a combined sequence and genetic mapping analysis in outbred rats that maps 355 quantitative trait loci for 122 phenotypes. We identify 35 causal genes involved in 31 phenotypes, implicating new genes in models of anxiety, heart disease and multiple sclerosis. The relationship between sequence and genetic variation is unexpectedly complex: at approximately 40% of quantitative trait loci, a single sequence variant cannot account for the phenotypic effect. Using comparable sequence and mapping data from mice, we show that the extent and spatial pattern of variation in inbred rats differ substantially from those of inbred mice and that the genetic variants in orthologous genes rarely contribute to the same phenotype in both species.
Keywords:Anxiety, Chromosome Mapping, DNA Sequence Analysis, Genetic Variation, Heart Diseases, Molecular Models, Multiple Sclerosis, Quantitative Trait Loci, Single Nucleotide Polymorphism, Animals, Mice, Rats
Source:Nature Genetics
ISSN:1061-4036
Publisher:Nature Publishing Group (U.S.A.)
Volume:45
Number:7
Page Range:767-775
Date:July 2013
Official Publication:https://doi.org/10.1038/ng.2644
PubMed:View item in PubMed

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