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Antinociceptive response in transgenic mice expressing rat tonin

Item Type:Article
Title:Antinociceptive response in transgenic mice expressing rat tonin
Creators Name:da Fonseca Pacheco, D. and da Fonseca Pacheco, C.M. and de Paula Lima, M. and Bader, M. and de Lima Souza, A. and Pesquero, J.L. and Castro Perez, A. and Duarte, I.D.G.
Abstract:Angiotensin II (Ang II) may be produced directly from angiotensinogen by tonin. Studies have demonstrated that Ang II and its metabolite Ang-(1-7) produce antinociception in pain animal models. The aim of the present study was to determine whether the transgenic mice that express rat tonin (TGM(rTon)) show altered nociceptive behavior and investigate the possible involvement of angiotensin metabolites. Nociception was evaluated using the thermal tail-flick and chemical acetic acid writhing tests, and the drugs were administered by intracerebroventricular and subcutaneous pathways, respectively. Probabilities less than 5% (P<0.05) were considered to be statistically significant (t test; ANOVA/Bonferroni's test). The results demonstrate that the transgenic mice showed an antinociceptive effect in the tail-flick and acetic acid writhing tests. In addition, it was observed that losartan, an AT1 receptor antagonist and A-779 (D-Ala7-Ang-(1-7)), a Mas receptor antagonist attenuated the antinociceptive behavior. Our data suggest that the Ang II produced in TGM(rTon) induces antinociception via the AT1 receptor, while the Ang-(1-7) produced from Ang II induced antinociception via the Mas receptor.
Keywords:Angiotensin II, Tonin, Antinociception, Losartan, A-779, Animals, Mice, Rats
Source:European Journal of Pharmacology
Page Range:1-5
Date:5 August 2013
Official Publication:https://doi.org/10.1016/j.ejphar.2013.04.032
PubMed:View item in PubMed

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