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It's the peptide-MHC affinity, stupid

Official URL:https://doi.org/10.1016/j.ccr.2013.04.004
PubMed:View item in PubMed
Creators Name:Kammertoens, T. and Blankenstein, T.
Journal Title:Cancer Cell
Journal Abbreviation:Cancer Cell
Volume:23
Number:4
Page Range:429-431
Date:15 April 2013
Abstract:Adoptively transferred T cells can reject large established tumors, but recurrence due to escape variants frequently occurs. In this issue of Cancer Cell, Engels et al. demonstrate that the affinity of the target peptide to the MHC molecule determines whether large tumors will relapse following adoptive T cell therapy.
ISSN:1535-6108
Publisher:Cell Press / Elsevier (U.S.A.)
Additional Information:Comment on: Cancer Cell 23(4):516-26
Item Type:Editorial

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