Bilateral vertebral artery dissection, agenesis of both ICAs, and connective tissue aberrations

Item Type:	Editorial
Title:	Bilateral vertebral artery dissection, agenesis of both ICAs, and connective tissue aberrations
Creators Name:	Lill, C.M. and Guenther-Kunkel, K. and Hoch, H. and Paul, F. and Grond-Ginsbach, C. and Hausser, I. and Zipp, F.
Abstract:	A 35-year-old woman presented with acute signs of stroke (appendix e-1 on the Neurology Web site at www.neurology.org). After initial CT with angiography, MRI with time-of-flight angiography confirmed agenesis of both internal carotid arteries (ICA; figure 1A). It revealed bilateral vertebral artery (VA) dissections and ischemias in both middle artery territories (figure 1, A-E). Skin biopsy microscopy (figure 2) was consistent with ultrastructural connective tissue syndrome (uCTD), for which no further evidence was found apart from mild hypermobility of the finger joints. The underlying uCTD with structural instability of the arterial walls and, due to the bilateral ICA agenesis, the increased blood flow in the vertebrobasilar circulation may have promoted VA dissection.
Source:	Neurology
ISSN:	0028-3878
Publisher:	American Academy of Neurology
Volume:	80
Number:	15
Page Range:	1442-1443
Date:	9 April 2013
Official Publication:	https://doi.org/10.1212/WNL.0b013e31828c2f8e
PubMed:	View item in PubMed

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