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Towards completion of the Earth's proteome

Item Type:Article
Title:Towards completion of the Earth's proteome
Creators Name:Perez-Iratxeta, C. and Palidwor, G. and Andrade-Navarro, M.A.
Abstract:New protein sequences are deposited in databases at an accelerating pace; however, many of these are homologous to known proteins and could be considered redundant. If all historical releases of the protein database are analysed using the original sequence-clustering procedure described here, the fraction of newly sequenced proteins that are redundant is increasing. We interpret this as an indication that the sequencing of the Earth's proteome-the complete set of proteins on Earth-is approaching completion. We estimate the approximate size of the Earth's proteome to be 5 million sequences, most of which will be identified during the next 5 years. As the Earth's proteome nears completion, cluster analysis of the protein database will become essential to identify under-explored taxa to which future sequencing efforts should be directed and to focus research on protein families without experimental characterization.
Keywords:Protein Sequence Database, Genomics, Sequencing Project, Database Annotation, Phylogenetic Analysis, Animals
Source:EMBO Reports
Publisher:Nature Publishing Group
Page Range:1135-1141
Date:1 December 2007
Official Publication:https://doi.org/10.1038/sj.embor.7401117
PubMed:View item in PubMed

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