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Divergence in cis-regulatory networks: taking the 'species' out of cross-species analysis

Item Type:Review
Title:Divergence in cis-regulatory networks: taking the 'species' out of cross-species analysis
Creators Name:Zinzen, R.P. and Furlong, E.E.
Abstract:Many essential transcription factors have conserved roles in regulating biological programs, yet their genomic occupancy can diverge significantly. A new study demonstrates that such variations are primarily due to cis-regulatory sequences, rather than differences between the regulators or nuclear environments.
Keywords:DNA-Directed RNA Polymerases, Gene Regulatory Networks, Genetic Transcription, Molecular Evolution, Species Specificity, Transcription Factors, Animals
Source:Genome Biology
ISSN:1465-6906
Publisher:BioMed Central (U.K.)
Volume:9
Number:11
Page Range:240
Date:4 November 2008
Official Publication:https://doi.org/10.1186/gb-2008-9-11-240
PubMed:View item in PubMed

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