Salmonella SL7207 application is the most effective DNA vaccine delivery method for successful tumor eradication in a murine model for neuroblastoma

Item Type:	Article
Title:	Salmonella SL7207 application is the most effective DNA vaccine delivery method for successful tumor eradication in a murine model for neuroblastoma
Creators Name:	Berger, E. and Soldati, R. and Huebener, N. and Hohn, O. and Stermann, A. and Durmus, T. and Lobitz, S. and Zenclussen, A.C. and Christiansen, H. and Lode, H.N. and Fest, S.
Abstract:	Attenuated Salmonella is an approved oral life vaccine that is currently entering pre-clinical cancer vaccination studies as a promising DNA carrier. In a syngeneic mouse model for neuroblastoma, oral gavage of Salmonella typhimurium (SL7207) carrying recent generated survivin DNA vaccines induced a stronger cellular anti-NB immune response than gene gun application or injection of lentivirally transduced bone marrow-derived DCs. The level of Salmonella-associated side effects was not significant as indicated by unaffected survivin-mediated hematopoiesis and wound healing. We believe that our findings provide an important baseline to translate Salmonella-based DNA vaccination into a clinical application for neuroblastoma.
Keywords:	Neuroblastoma, SL7207, Dendritic Cells, Gene Gun, Lentiviral Particle, Animals, Mice
Source:	Cancer Letters
ISSN:	0304-3835
Publisher:	Elsevier
Volume:	331
Number:	2
Page Range:	167-173
Date:	1 May 2013
Official Publication:	https://doi.org/10.1016/j.canlet.2012.12.026
PubMed:	View item in PubMed

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