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Long-term lanreotide treatment in six patients with congenital hyperinsulinism

Item Type:Article
Title:Long-term lanreotide treatment in six patients with congenital hyperinsulinism
Creators Name:Kuehnen, P. and Marquard, J. and Ernert, A. and Meissner, T. and Raile, K. and Wannenmacher, G. and Blankenstein, O.
Abstract:BACKGROUND: Medical treatment is a substantial therapeutic measure to achieve glycemic control and prevent hypoglycemic brain damage without surgery in patients with congenital hyperinsulinism (CHI). However, only few drugs are available and even fewer are approved as a medical therapy to maintain normal blood glucose levels. The established therapies are demanding for caregivers and complicated by different side effects such as gastrointestinal symptoms, hypertrichosis, and obesity. Therefore, it is important to develop new strategies to improve blood glucose control. METHODS: We report the use of the very-long-acting somatostatin analogue lanreotide autogel in 6 patients with CHI over a mean duration of 40.8 months. Blood glucose levels before and after the start and dosage titration of lanreotide in these patients are compared. RESULTS: In 3 of 6 patients, switching to lanreotide raised mean blood glucose levels and reduced individually as well as overall the risk for hypoglycemic episodes (odds ratio 0.38) significantly. CONCLUSION: Lanreotide autogel can be used as an alternative pharmacological treatment and may be beneficial in conservatively treated patients with CHI.
Keywords:Congenital Hyperinsulinism, Lanreotide, Beta Cell, Insulin, Treatment
Source:Hormone Research in Paediatrics
Page Range:106-112
Date:September 2012
Official Publication:https://doi.org/10.1159/000341525
PubMed:View item in PubMed

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